2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-
YK-4-279
CAS: 1037184-44-3
Molecular Formula: C17H13Cl2NO4
2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]- - Names and Identifiers
2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]- - Physico-chemical Properties
| Molecular Formula | C17H13Cl2NO4 |
| Molar Mass | 366.2 |
| Density | 1.456 |
| Melting Point | 149-151℃ |
| Boling Point | 608.9±55.0 °C(Predicted) |
| pKa | 10.43±0.20(Predicted) |
| Storage Condition | Store at -20° C. |
| In vitro study | YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion. |
| In vivo study | In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors. |
2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.731 ml | 13.654 ml | 27.307 ml |
| 5 mM | 0.546 ml | 2.731 ml | 5.461 ml |
| 10 mM | 0.273 ml | 1.365 ml | 2.731 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.546 ml |
Last Update：2024-01-02 23:10:35
2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]- - Introduction
YK-4-279 is a chemical substance whose chemical name is 3-(3-(5-fluoro-2-methyl-4-phenyl)-4-(4-methyl -1H-quinazol-2-yl) thiazol-2-yl)-N-(1-substituted -1H-pyrazol-4-yl) aniline.
YK-4-279 is a compound that acts as an inhibitory ETV1 transcription factor. The ETV1 transcription factor plays a key role in some types of cancer and thus YK-4-279 serve as a potential anticancer drug.
The method of preparing YK-4-279 can be obtained by a series of synthetic reactions. The synthesis method includes the substitution reaction of p-benzaldehyde, the reaction of thionyl chloride with substituted pyrazoles and substituted thiazoles, and the reaction of aniline with substituted thiazole oxazolones.
Regarding the safety information of YK-4-279, because it may have potential anti-tumor activity, a high degree of biosafety assessment may be required. Appropriate laboratory procedures and personal protective measures need to be followed when using this compound. In addition, laboratory workers should also have detailed information on the safety of the compound before conducting experiments and comply with relevant chemical management and waste disposal regulations.
YK-4-279 is a compound that acts as an inhibitory ETV1 transcription factor. The ETV1 transcription factor plays a key role in some types of cancer and thus YK-4-279 serve as a potential anticancer drug.
The method of preparing YK-4-279 can be obtained by a series of synthetic reactions. The synthesis method includes the substitution reaction of p-benzaldehyde, the reaction of thionyl chloride with substituted pyrazoles and substituted thiazoles, and the reaction of aniline with substituted thiazole oxazolones.
Regarding the safety information of YK-4-279, because it may have potential anti-tumor activity, a high degree of biosafety assessment may be required. Appropriate laboratory procedures and personal protective measures need to be followed when using this compound. In addition, laboratory workers should also have detailed information on the safety of the compound before conducting experiments and comply with relevant chemical management and waste disposal regulations.
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: YK-4-279 Visit Supplier Webpage Request for quotationCAS: 1037184-44-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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